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Death Receptors and Cognate Ligands in Cancer download ebook

Death Receptors and Cognate Ligands in Cancer download ebook

Death Receptors and Cognate Ligands in Cancer by Holger Kalthoff

Death Receptors and Cognate Ligands in Cancer
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Author: Holger Kalthoff
Page Count: 294 pages
Published Date: 14 Mar 2012
Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG
Publication Country: Berlin, Germany
Language: English
Format: eBook
ISBN: 9783642260766
File size: 37 Mb
File Name: death.receptors.and.cognate.ligands.in.cancer.pdf
Download Link: death receptors and cognate ligands in cancer
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Death receptors play a central role in directing apoptosis in mammalian cells. This process of active cell death is important for a number of biological processes, e.g. for the regulation of the immune system. Death receptors are cell surface receptors that transmit apoptotic signals initiated by corresponding death ligands. Many complex signaling pathways are activated and apoptosis is the final result of a complex biochemical cascade of events. Besides their role in the induction of cell death, evidence now exists that death receptors are able to activate several non-apoptotic signaling pathways which, depending on cellular context, may lead to apoptosis resistance, secretion of pro-inflammatory proteins, proliferation and invasive growth of cancer cells. This book looks at the molecular basis of death receptor signaling and the role of death receptors in cancer development.

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